Heterogeneity of Human Circulating Anticoagulants Against Antihemophilic

The heterogeneity of human circulating serum. In one circulating anticoagulant, anticoagulants against antihemophilic light chain specificity could not be demonfactor (AHF, factor VIII) observed in seven strated with small amounts of antiserum, patients, both with and without classic and with larger amounts, only lambda hemophilia, was investigated by neutrallight chain specificity was revealed. ization of their activity with antiserums Whether or not this circulating anticoagudirected to whole IgG and to lambda and lant really contained a single light chain kappa light chains. All seven anticoagutype could not be ascertained with our Iants were immunoglobulins. Six aptechnique. The evidence presented sugpeared to contain both kinds of light gested that circulating anticoagulant antichains, although the dual light chain combodies against AHF are polyclonal in position of two of these could be demonnature. strated only at high concentration of anti-