Heterogeneity of Human Circulating Anticoagulants Against Antihemophilic

نویسندگان

  • Man-Chiu Poon
  • Alan C. Wine
  • Oscar D. Ratnoff
  • George M. Bernier
چکیده

The heterogeneity of human circulating serum. In one circulating anticoagulant, anticoagulants against antihemophilic light chain specificity could not be demonfactor (AHF, factor VIII) observed in seven strated with small amounts of antiserum, patients, both with and without classic and with larger amounts, only lambda hemophilia, was investigated by neutrallight chain specificity was revealed. ization of their activity with antiserums Whether or not this circulating anticoagudirected to whole IgG and to lambda and lant really contained a single light chain kappa light chains. All seven anticoagutype could not be ascertained with our Iants were immunoglobulins. Six aptechnique. The evidence presented sugpeared to contain both kinds of light gested that circulating anticoagulant antichains, although the dual light chain combodies against AHF are polyclonal in position of two of these could be demonnature. strated only at high concentration of anti-

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منابع مشابه

Heterogeneity of human circulating anticoagulants against antihemophilic factor (factor VIII).

The heterogeneity of human circulating anticoagulants against antihemophilic factor (AHF, factor VIII) observed in seven patients, both with and without classic hemophilia, was investigated by neutralization of their activity with antiserums directed to whole IgG and to lambda and kappa light chains. All seven anticoagulants were immunoglobulins. Six appeared to contain both kinds of light chai...

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Heterogeneity of Human Circulating Anticoagulants Against Antihemophilic Factor

The heterogeneity of human circulating serum. In one circulating anticoagulant, anticoagulants against antihemophilic light chain specificity could not be demonfactor (AHF, factor VIII) observed in seven strated with small amounts of antiserum, patients, both with and without classic and with larger amounts, only lambda hemophilia, was investigated by neutrallight chain specificity was revealed...

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Techniques for demonstration of the specificity of circulating anticoagulants against antihemophilic factor (factor VIII), with studies of two cases possibly related to diphenylhydantoin therapy.

Circulating anticoagulants against antihemophilic factor (AHF, factor VIII) sometimes seem to inactivate other clotting factors as well. Measurements of the concentration of clotting factors in highly diluted plasma, or after neutralization of the anticoagulant with purified AHF, have demonstrated the specific nature of the anticoagulant in a patient under treatment with diphenylhydantoin. A se...

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Immunologic Evidence That the Antihemophilic Factor ( Factor VIH ) - like Material in Hemophilic Plasma Possesses a Nonfunctional Low

Antihemophilic factor (AHF, factor VIII) is a macromolecule that can be dissociated into two subcomponents. One, of high molecular weight (MW), forms precipitates with heterologous antiserum against AHF and supports ristocetin-induced aggregation of platelets. The other, of lower MW, has procoagulant activity. The plasma of patients with classic hemophilia contains a form of AHF with properties...

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Immunologic Evidence That the Antihemophilic Factor ( Factor VIH ) - like Material in Hemophilic Plasma

Antihemophilic factor (AHF, factor VIII) is a macromolecule that can be dissociated into two subcomponents. One, of high molecular weight (MW), forms precipitates with heterologous antiserum against AHF and supports ristocetin-induced aggregation of platelets. The other, of lower MW, has procoagulant activity. The plasma of patients with classic hemophilia contains a form of AHF with properties...

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تاریخ انتشار 2005